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Faculty of Biology, Chemistry & Earth Sciences

Laboratory of Molecular Parasitology

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Research themes

Ersfeldlab

1. The cytoskeleton of Trypanosoma brucei

The cytoskeleton of trypanosomes is defined by a corset of subpellicular microtubules. We investigate how the dynamics of these microtubule arrays are regulated and contribute to morphological adaptations during the life cycle of the parasite. A particular focus is on the role of microtubule posttranslational modifications, such as polyglutamylation. This is a joint project with the Department of Experimental Physics (Prof. Matthias Weiss), funded by the DFG priority program "Physics of Parasites".

We use a variety of molecular biology techniques, such as mutagenesis, epitope-tagging, gene deletions and RNA interference. Equally important are, however, cell biology techniques to probe the 3-dimensional structure of the cells. Techniques such as immunofluorescence microscopy, advanced digital image analysis (cell tracking, motility analysis) and electron microscopy are routinely employed.

Ersfeldlab

The mitotic spindle stained with anti-tubulin antibody KMX (see Ogbadoyi et al., Chromosoma, 2000)

Ersfeldlab

A calpain-like protein localises to the flagellum of T. brucei (see Liu et al. MBP, 2010).

Ersfeldlab

NUP1, a protein of the nuclear envelope in T. brucei (see Ogbadoyi et al., Chromosoma, 2000)


Webmaster: Univ.Prof.Dr. Klaus Ersfeld

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